FP466INTERACTION BETWEEEN PHOSPHATE BINDERS, VITAMIN K AND VASCULAR CALCIFICATION, IN A CROSS OVER STUDY
نویسندگان
چکیده
منابع مشابه
Phosphate binders affect vitamin K concentration by undesired binding, an in vitro study
BACKGROUND Vascular calcification is a major contributing factor to mortality in end stage renal disease (ESRD). Despite the efficacy of phosphate binders to improve hyperphosphatemia, data on vascular calcification are less clear. There seems to be a difference in attenuation or delay in progression between different binders. In this in vitro experiment we tested whether phosphate binders coul...
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Vitamin K is a cofactor in the -glutamyl carboxylation pathway, a posttranslational conversion of specific glutamate residues into -carboxyglutamic acid (Gla) residues, catalyzed by the endoplasmic reticulum enzyme -glutamyl carboxylase. The substrates of carboxylase are the so-called vitamin K–dependent proteins, which are involved in diverse physiological processes such as blood coagulation, ...
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Vitamin K-dependent proteins (VKDPs) require carboxylation to become biologically active. Although the coagulant factors are the most well-known VKDPs, there are many others with important physiologic roles. Matrix Gla Protein (MGP) and Growth Arrest Specific Gene 6 (Gas-6) are two particularly important VKDPs, and their roles in vascular biology are just beginning to be understood. Both functi...
متن کاملEvaluation of Vitamin D Level and its Correlation to Vascular Calcification in Hemodialysis Patients
Introduction: Compared with the general population, hemodialysis patients are at increased risk of vascular calcification, which in turn is associated with an increased risk of mortality. Regarding the role of vitamin D in bone formation, regulation of calcium, phosphate and iPTH level and correlation of these variables in survival, this study was performed to evaluate the vitamin D serum level...
متن کاملIron-based phosphate binders: do they offer advantages over currently available phosphate binders?
Increased cardiovascular morbidity and mortality has been associated with the hyperphosphatemia seen in patients with end-stage chronic kidney disease (CKD). Oral phosphate binders are prescribed in these patients to prevent intestinal absorption of dietary phosphate and reduce serum phosphate. In prospective observational cohorts they have shown to decrease all-cause and cardiovascular mortali...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2019
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfz106.fp466